Site location, and choice of device manufacturer are significant.
To double natural atmospheric shielding, you need 2-3 meters of concrete/soil.
Errors at 40,000 feet are ~200 times greater than at sea level in the UK (as an experiment, run "memtest86" on your laptop next time you are on a flight).
Do not only effect memory devices (Intel, and IBM have added a great deal of ECC and redundancy to their recent CPUs).
Cell logical vs. physical layout is very important with respect to soft errors, and EDAC.
Severity of problem is also application specific (e.g. working set, read/write access patterns).